What side effects may I experience with the Estradiol Cream?

Common side effects with starting vaginal estrogen can include: vaginal discharge, vulvar irritation, abdominal discomfort, nausea or vomiting, headache, and breast pain. You should notify your provider if you experience any concerning symptoms such as postmenopausal bleeding, severe allergic reaction, visual disturbances, weakness or numbness of your extremities, chest pain, or any other concerning symptoms.