Will taking DoxyPEP increase antibiotic resistance?

Resistance is always a potential risk with antibiotics, however it's important to weigh the risks against the benefits as you would with any potential treatment. There is evidence to show that DoxyPEP works to prevent STIs that we are already seeing antibiotic resistance in (like gonorrhea). Drug resistance with DoxyPEP is currently being studied in individuals that use this treatment for STI prevention, but given the increase in STI incidence in the US over the past few years, this treatment is highly valuable in preventing their spread.