When should I take Zofran?

If you're taking Zofran to prevent nausea caused by medication, you can take one Zofran tablet 30 minutes before your prescribed dose of medication, which allows for enough time for the Zofran to kick in and prevent those uncomfortable waves of nausea. Keep in mind that the maximum dose of Zofran is one pill, three times daily every 8 hours. Taking Zofran with antibiotics, for example, can help you reduce your side effects so you can finish your medication and prevent your infection from returning.