Does Zofran have side effects?

Side effects with Zofran are rare, but it is possible to experience mild side effects such as:

• Constipation
• Headache
• Drowsiness
• Diarrhea

One important benefit is that Zofran can be taken with or without food! It can be hard to eat when you are feeling nauseous, so don’t feel pressure to eat before taking it. You will tolerate it just fine!