What is the difference between Tretinoin and Spironolactone?

Tretinoin is a topical prescription retinoid that can help reduce acne by increasing cell turnover to reduce inflammation and clogged pores. While it can be an effective treatment, it’s well-known to cause dryness, peeling, and redness in the early months of treatment while your skin adjusts.

Both oral and topical Spironolactone act on the hormonal causes of acne, specifically androgens, which can cause excess oil. Topical Spironolactone acts locally at the surface of the skin and, as a result, has fewer systemic side effects than oral Spironolactone, and is gentler than tretinoin. Tretinoin and Spironolactone can be used together to address acne—tailor your routine to fit your preferences!